Activity against a number of parasites has also been demonstrated Its cellular pharmacokinetics, postantibiotic effect and interactions with host Spiramycin is a 16memberedring macrolide with an antibacterial spectrum characteristic of this class of drugs and including Gramnegative and Grampositive cocci, Parvobacteriaceae and some intracellular organisms;Molecular structure The molecular structure is based on structures generated from information available in ECHA's databases If generated, an InChI string will also be generated and made available for searching This information is only displayed if the substance is welldefined, its identity is not claimed confidential and there is sufficient information available in ECHA's databases for ECHA's algorithms to generate a molecular structure
Spiramycin New Drug Approvals
Spiramycin structure and chemical name
Spiramycin structure and chemical name-Spiramycin II is a macrolide antibiotic produced by various Streptomyces species It has a role as an antibacterial drug, an antimicrobial agent and a bacterial metabolite It is an aldehyde, a disaccharide derivative, an ether, a macrolide, a tertiary amino compound and an acetate esterFind and related products for scientific research at MilliporeSigma
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Spiramycin, a widely used veterinary macrolide antibiotic, was found at traceable levels (nanograms per litre range) in Po River water (NItaly) The aqueous environmental fate of this antibiotic compound was studied through drug decomposition, the identification of the main and secondary transformation products (TPs), assessment of mineralisation and the investigationUsing a structure estimation method based on molecular connectivity indices(1), the Koc of spiramycin can be estimated to be 140(SRC) According to a classification scheme(2), this estimated Koc value suggests that spiramycin is expected to have high mobility in soil Estimated pKa values of spiramycin are 7 and 928(3), indicating that this compound will exist almostSpiramycin was effective against a number of such strains in vivo, but erythromycin had little effect against these infections Investigation into the distribution of the antibiotics in the serum and tissues of mice showed that spiramycin was maintained in tissues (lung, liver, kidney, spleen and heart) at higher concentrations and for a longer period than erythromycin, although erythromycin
Monoisotopic mass Da;Biochem/physiol Actions Spiramycin is a 16membered ring macrolide antibiotic from Streptomyces ambofaciens It inhibits bacterial protein synthesis at the level of peptidytRNA dissociation from ribosomes It is mainly used against Grampositive bacteriaAcetylspiramycin C45H76N2O15 CID structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more
Structure, properties, spectra, suppliers and links for Spiramycin I An antibiotic used for the treatment and control of a number of bacterial and mycoplasmal infections in animals and also used as a growth promotor Availability status Introduction & key dates 00, Europe Examples of species treated Poultry, Sheep, Cattle, Pigs, Cats, Dogs Chemical structure IsomerismSpiramycin, hexanedioate (11) (salt) The 'Substance identity' section is calculated from substance identification information from all ECHA databases The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas Some substance identifiers may
Spiramycin Iii Cas 52 7
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Chemical Structure and Safety of Spiramycin Jacques Descotes 1 Drug Investigation volume 6, pages 43–48 (1993)Cite this article 29 Accesses 3 Citations Metrics details Summary Since the introduction of spiramycin, thousands of patients have been treated with the drug and few have developed severe adverse reactions Gastrointestinal disorders were usually mild andSpiramycin I Molecular Formula C 43 H 74 N 2 O 14;Were identified and their structure confirmed by mass spectrometry Residues of parent drug accounted for 04 mg/kg, while residues of spiramycin adducts with Lcysteine represented 105 mg/kg, and neospiramycin adducts with Lcysteine accounted for an additional 22 mg/kg of residues However, the transformation into cysteine compound is
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A macrolide antibiotic produced by Streptomyces ambofaciens The drug is effective against grampositive aerobic pathogens, N gonorrhoeae, and staphylococci It is used to treat infectionsCrystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center Their location suggests that they inhibit protein synthesis by blocking theAverage mass Da;
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Spiramycin is a macrolide antibiotic and antiparasitic It is used to treat toxoplasmosis and various other infections of soft tissues Although used in Europe, Canada and Mexico, 1 spiramycin is still considered an experimental drug in the United States, but can sometimes be obtained by special permission from the FDA for toxoplasmosis in the first trimester of pregnancy 2Structure, properties, spectra, suppliers and links for spiramycin IIISpiramycin I ChEBI ID CHEBI Definition A macrolide antibiotic produced by various Streptomyces species that is used to treat toxoplasmosis and various other infections of soft tissues Stars This entity has been manually annotated by the ChEBI Team Secondary ChEBI IDs
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Keyword 'spiramycin' Spiramycin Spiramycin Synonyms Formacidine, Spiramycin CAS Number EC NumberChemical structure macrolide Application Spiramycin is a macrolide antibiotic that is commonly used to treat infections of soft tissues It has been used to treat bronchopulmonary infections in adults and has been used to study septicemia in mice Biochem/physiol Actions Spiramycin is a 16membered ring macrolide antibiotic from Streptomyces ambofaciens It inhibits bacterialTo the Spiramycin residue monograph prepared by the 43rd meeting of the Committee and published in FAO Food and Nutrition Paper 41/7, Rome 1995 Introduction As the sponsor was unable to provide a validated chemical method for the analysis of spiramycin and neospiramycin residues in pig tissues to the 43rd JECFA meeting in 1994, it was not possible to estimate the
Chemical Structures Of Main Components Of Spiramycin And Its Related Download Scientific Diagram
Chemical Structures Of Main Components Of Spiramycin And Its Related Download Scientific Diagram
Tetrahydrofuranyl and tetrahydropyranyl derivatives of neospiramycin I at 3 and/or 4' position were synthesized In vitro and in vivo activities of these derivatives were correlated with the position and configuration of acetal groups The most effective derivative, 3a, 4'adiOtetrahydrofuranylneospiramycin I was comparable to spiramycin I Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center Their location suggests that they inhibit protein synthesis byCrystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15membered macrolide, azithromycin, show that they bind in the polypeptide exit tunnel adjacent to the peptidyl transferase center Their location suggests that they inhibit protein synthesis by blocking the
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PLQDGTZICFBBSODPUAUXBSSAN Spiramycin adipate Similar structures search, synonyms, formulas, resource links, and other chemical informationSpiramycin II Molecular Formula C 45 H 76 N 2 O 15; As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards The RCSB PDB also provides a variety of tools and resources Users can perform simple and advanced searches based on annotations relating to sequence, structure and function These molecules are visualized, downloaded, and analyzed by users who range from
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CHEBI spiramycin II A macrolide antibiotic produced by various Streptomyces species This entity has been manually annotated by the ChEBI Team No supplier information found for this compound A molecular entity capable of accepting a hydron from a donor (Br o nsted acid) A drug used to treat or prevent bacterial infectionsSummarySince the introduction of spiramycin, thousands of patients have been treated with the drug and few have developed severe adverse reactions Gastrointestinal disorders were usually mild and transient, and allergic reactions were quite uncommon Liver injury was described only once and drug interactions have not been reported The safety profile of this 16membered lactoneDas Antibiotikum Spiromycin besitzt die chemische Summenformel C 43 H 74 N 2 O 14 Bei Zimmertemperatur liegt die Substanz als festes, kristallines Pulver vor In dieser Form besitzt einen leicht hygroskopischen Charakter, d h es zieht Wasser aus der Luft an In Wasser ist der Wirkstoff nur schwach löslich
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Spiramycin is a 16membered ring macrolide (antibiotic) It was discovered in 1952 as a product of Streptomyces ambofaciens As a preparation for oral administration it has been used since 1955, in 1987 also the parenteral form was introduced into pr Read More Please waitSpiramycin U contains total 133 bond(s);Monoisotopic mass Da;
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Chemical structure and selected properties of spiramycin and metronidazole Physicochemical data from National Center for Biotechnology Information 51 and Kalhori 26 Stock solutions of both antibiotics were prepared at 100 mg L −1 in highpurity Milli Q water62 nonH bond(s), 4 multiple bond(s), 11 rotatable bond(s), 4 double bond(s), 3 sixmembered ring(s), 1 ester(s) (aliphatic), 1 aldehyde(s) (aliphatic), 2 tertiary amine(s) (aliphatic), 4 hydroxyl group(s), 3 secondary alcohol(s), 1 tertiary alcohol(s) and 7 ether(s) (aliphatic) Learn more about Spiramycin I chemical structure at MolInstinctsSpiramycin adipate C49H84N2O18 CID structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more
Chemical Structures Of Main Components Of Spiramycin And Its Related Download Scientific Diagram
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Average mass 50 Da;Spiramycin is a complex formed by three major components (I–III), which differ in the substituent at position 3 of the lactone nucleus The spiramycins are more stable than erythromycin A in an acidic medium Roxithromycin is highly stable at pH 42 (Figure 1414) Clarithromycin is 6Omethylerythromycin A, and the hydroxyl at position 11 remains free A degradation productSpiramycin Structure Close Systematic / IUPAC Name 2(4 R ,5 S ,6 S ,7 R ,9 R ,10 R ,11 E ,13 E ,16 R )6(2 S ,3 R ,4 R ,5 S ,6 R )5(2 S ,4 R ,5 S ,6 S )4,5Dihydroxy4,6dimethyloxan2yloxy4(dimethylamino)3hydroxy6methyloxan2yloxy10(2 S ,5 S ,6 R )5(dimethylamino)6methyloxan2yloxy4hydroxy5methoxy9,16dimethyl2oxo1
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Spiramycin I contains total 136 bond(s); Both structural features seem to increase toxicity Removal of the nitro group leading to augmented toxicity was also confirmed through QSAR analysis of clothianidin and thiamethoxam and their transformation products The proposed structures corresponding to m/z = 247 and 263 of thiametoxam serve as examples Unfortunately, no suitable QSAR model could be used forWe are Spiramycin CAS suppliers and specialize ,,, etc
A Chemical Structure Of Spiramycin Pk 7 9 B Dose Dependent Download Scientific Diagram
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62 nonH bond(s), 4 multiple bond(s), 10 rotatable bond(s), 4 double bond(s), 3 sixmembered ring(s), 1 ester(s) (aliphatic), 1 aldehyde(s) (aliphatic), 1 tertiary amine(s) (aliphatic), 6 hydroxyl group(s), 4 secondary alcohol(s), 2 tertiary alcohol(s) and 7 ether(s) (aliphatic) Learn more about Spiramycin U chemical structure at MolInstincts
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